Selected abstracts on retinoids, beta-carotene and cancer by Richard C. Moon

Cover of: Selected abstracts on retinoids, beta-carotene and cancer | Richard C. Moon

Published by U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Technical Information Service, 1986. in Bethesda, MD, Springfield, Va .

Written in English

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Subjects:

  • Cancer -- Abstracts.,
  • Carotenes -- Abstracts.,
  • Retinoids -- Abstracts.

Edition Notes

Book details

StatementRichard C. Moon.
GenreAbstracts.
SeriesOncology overview
ContributionsInternational Cancer Research Data Bank.
The Physical Object
Paginationvii, 104 p. ;
Number of Pages104
ID Numbers
Open LibraryOL17833719M

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Carotenoids and Retinoids: Molecular Aspects and Health Issues by Lester Packer (Editor) ISBN ISBN Why is ISBN important. ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book. Retinoids and Carotenoids in Dermatology (Basic and Clinical Dermatology) 1st Edition as well as advance biomedical research in relation to cancer treatment and immunology.

Providing an in-depth update on the pharmacology, pharmacodynamics, and new applications of retinoid therapy, this source also addresses topics outside of dermatology Format: Hardcover.

This up-to-date reference describes how retinoids and carotenoids function in the skin and how they can be utilized to prevent and treat a wide variety of skin diseases, as well as advance biomedical research in relation to cancer treatment and immunology.

Providing an in-depth update on the pharmacology, pharmacodynamics, and new applications of. This up-to-date reference describes how retinoids and carotenoids function in the skin and how they can be utilized to prevent and treat a wide variety of skin diseases, as well as advance biomedical research in relation to cancer treatment and immunology.

Providing an in-depth update on the pharmacology, pharmacodynamics, and new applications ofCited by: Vitamin A analogs (retinoids) suppress oral and lung carcinogenesis in animal models and prevent the development of second primary tumors in head, neck, and lung cancer patients.

These effects result from changes in the expression of genes that regulate cell growth and by:   My colleague, Dr. Robert Russell, is an internationally known expert in the field of vitamin A, also known as retinol, and the related substances called retinoids and carotenoids.

Some of these, such as beta-carotene, are thought to have anti-cancer and other health benefits; and many people take one or more of them as a diet supplement.

Barua, AB & Olson, JA () Beta-carotene is converted primarily to retinoids in rats in vivo. Journal of Nutrition– Berggren Soderlund, M, Fex, G & Nilsson-Ehle, P () Decreasing serum concentrations of all-trans, cis retinoic acids.

Recent reports showing the specific actions of the oxidation products of carotenoids on the growth of several cancer cells (7,8) have enforced the need for elucidating oxidation products in biological tissues.

Some of the products would also be interesting as markers which could indicate the antioxidant nature of carotenoids in by: Total tumor regression was found in 30% of phycotene animals, 20% of beta carotene animals and 15% of canthaxanthin animals after four weeks.

Partial tumor regression was found in the remaining 70% of phycotene animals, 80% of beta carotene animals and 85% of canthaxanthin by: Cancer Information Dissemination and Analysis Center for Virology, Immunology, and Biology. Title(s): Selected abstracts on retinoids, beta-carotene, and cancer/ Richard C.

Moon, consulting reviewer. Retinol is not found in plants but these do contain a retinol precursor called beta-carotene.

Beta-carotene is converted to retinol by enzymes located in cells of the intestinal mucosa (Nagao Retinoids and Carotenoids in Dermatology - CRC Press Book This up-to-date reference describes how retinoids and carotenoids function in the skin and how they can be utilized to prevent and treat a wide variety of skin diseases, as well as advance biomedical research in relation to cancer.

Carotenoids—there are recognized types found in fruits and vegetables—are labile compounds that can create a number of breakdown products whose significance remains to be determined.

The carotenoids most commonly found in the skin are lycopene, beta-carotene, and oxidized carotenoids (xanthophylls), Cited by: 1.

“Vitamin A” refers to retinol, retinyl esters, retinal, and retinoic acid. Structurally, these carbon compounds all contain a cyclohexene ring (with three methyl groups substituted on it), connected to an isoprenoid chain (H 2 C C (CH 3) CH CH 2) which terminates in a polar carbon-oxygen functional group: CH 2 OH for retinol, CHO for retinal, and COOH for retinoic acid ().Author: Neal E.

Craft, Harold C. Furr. Retinoids are a class of lipophilic isoprenoid molecules that are related chemically to vitamin A [1]. Retinoids are composed of a β-ionone ring and a polyunsaturated side chain, with an alcohol (retinol), an aldehyde (retinal), a carboxylic acid (retinoic acid), or an ester (retinyl esters) functional group (Figure 1A).

In conclusion, dietary vitamin A, beta-carotene and lycopene might inversely correlate with pancreatic cancer. Pancreatic cancer is a devastating disease with poor prognosis and the 5-year survival rate remains low at 8% by: Various aspects of vitamin A deficiency and studies on carotenoids and retinoids in cancer development and prevention are reviewed in some detail.

Discover the world's research 16+ million members. Importantly, CARET, the largest chemoprevention trial to date of vitamin A and lung cancers, found a significantly increased risk of lung cancers in the retinol and beta carotene by: Beta-Carotene is a naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities.

As an anti-oxidant, beta carotene inhibits free-radical damage to DNA. This agent also induces cell differentiation and apoptosis of some tumor cell types, particularly in early stages of tumorigenesis, and enhances.

It was found that there was an inverse correlation between vitamin A, beta-carotene and lycopene intake and the risk of pancreatic cancer (for vitamin A, pooled OR = Cited by: Carotenoids comprise a class of natural fat-soluble pigments which are found in numerous fruits and vegetables.

The consumption of a diet rich in carotenoids has been epidemiologically correlated with a lower risk for several diseases. beta-carotene cancer prevention study: P.S. BernsteinTransformations of selected carotenoids in plasma Cited by:   Cancer Res.

Jun 1; 47 (11)– Omenn GS, Goodman G, Grizzle J, Thornquist M, Rosenstock L, Barnhart S, Anderson G, Balmes J, Cherniack M, Cone J, et al. CARET, the beta-carotene and retinol efficacy trial to prevent lung cancer in asbestos-exposed workers and in smokers.

Anticancer Drugs. Feb; 2 (1)– Omenn GS. In the ATBC Cancer Prevention Study, new cases of lung cancer were diagnosed, yielding a relative risk of lung cancer of among subjects who received beta carotene (with or without alpha Cited by: Carotenoids are one of the most widespread pigment groups distributed in nature, and more than natural carotenoids have been described so far, and new carotenoids are introduced each year.

Carotenoids are derived from 4 terpenes, including totally 40 carbon atoms. Carotenoids are naturally synthesized by cyanobacteria, algae, plants, some fungi, and some bacteria, but not made by : Oguz Merhan. Retinoid, retinoic acid receptor beta and breast cancer Article Literature Review in Breast Cancer Research and Treatment 76(2) December with 26 Reads How we measure 'reads'.

This in turn led to large dietary intervention studies, some of which explored the use of high doses of β-carotene in smokers and asbestos workers. Two of the most influential studies were the Beta-Carotene and Retinol Efficacy Trial (CARET) and the Alpha-Tocopherol Beta-Carotene Cancer Prevention Trial (ATBC).

However, the results from such Cited by:   The Alpha-tocopherol Beta-carotene Cancer Prevention Group () The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers.

The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. N Engl J Med– Cited by: 6. To determine the levels of carotenoids, retinoids, and tocopherols in normal and cataractous human lenses. Concentrations of carotenoids, retinoids, and tocopherols were measured by high.

Introduction Retinoids are members, precursors or derivatives of the A vitamins. These include beta carotene, isotretinoin, tretinoin, 9 cis retinoic acid, and etretinate. The pharmacological uses of retinoids are diverse. Retinoids are used in the treatment of acne, vitamin A deficiency, photosensitivity.

Two trials, the Finnish Alpha‐Tocopherol, Beta‐Carotene Cancer Prevention (ATBC) trial and the Beta‐Carotene and Retinol Efficacy Trial (CARET), were conducted exclusively among individuals at a high risk for lung cancer.

3, 4 In the ATBC study, 3 participants were aged 50 to 69 years and smoked ≥5 cigarettes per day at the time of Cited by: It has been proposed that carotenoids and retinoids are agents that may prevent these disorders. METHODS: We conducted a multicenter, randomized, double-blind, placebo-controlled primary prevention trial -- the Beta Carotene and Retinol Efficacy Trial -- involving a total of 18, smokers, former smokers, and workers exposed to asbestos.

This article has no abstract; the first words appear below. To the Editor: In discussing in his editorial the "opposite results" of the trials of beta carotene and isotretinoin in cancer.

Beta carotene is a plant-derived carotenoid with pro—vitamin A (retinol) activity that has been proposed as a possible preventive agent against cancer. 1, 2 Numerous case–control studies have Cited by:   Analysis of retinoids and carotenoids may now be considered a relatively mature field.

Although specific challenges remain, there is a corpus of accepted techniques for extraction of these compounds from biological samples and for their qualitative and quantitative by: Retinoids molecular therapeutics Chair: Ethan Dmitrovsky.

of tumor progression in triple negative breast cancer models involves activation of retinoic acid receptor alpha. Martin Sanders, Update on clinical development of the selective RXR agonist compound IRX Nadine Darwiche (Short Talk), From admantyl retinoids to DNA. Grant Number: 5R01CA PI Name: Robert Russell Project Title: Biologic Activity of Beta-Carotene Metabolites Abstract: DESCRIPTION (provided by applicant): Understanding the mechanism(s) of anticarcinogenic and procarcinogenic effects of beta-carotene is important due to continuing interest in the potential use of carotenoids as chemopreventive agents -- and the conflicting.

Abstract. Epidemiological investigations have indicated an inverse relationship between vitamin A intake and risk for developing cancer, and over the past several years an extensive effort has been directed towards understanding the mechanism by which vitamin A and retinoids (analogs of vitamin A) inhibit carcinogenesis.

1,2Cited by: However, beta-carotene has not yet been used in clinical trials to evaluate its potential for the treatment of breast cancer. A large-scale clinical trial is necessary to determine the effectiveness of beta-carotene in reducing the chances of recurrence of breast cancer, and in preventing the development of new by:   Retinoids are of special interest in cancer research owing to their antiproliferative and cancer-preventative properties.

They have been used successfully to cure acute promyelocytic leukaemia (APL) and can suppress carcinogenesis in a variety of Cited by:. Study cohort. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study was established between and when 29 male smokers aged 50–69 years living in southwestern Finland Cited by:   Beta-carotene is not effective in treating heart disease, cancer, or HIV or preventing cataracts or macular degeneration.

Beta-carotene is an antioxidant that is found in yellow and orange fruits, such as apricots, cantaloupe, and papaya, as well as squash, carrots, sweet potatoes, pumpkin, leafy greens, and broccoli.Mills EE: The modifying effect of beta-carotene on radiation and chemotherapy induced oral mucositis.

Br J Cancer, Crossref, Medline, Google Scholar: 4. Kennedy AR, Krinsky NI: Effects of retinoids, beta-carotene, and canthaxanthin on UV- and X Cited by:

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